Hair Loss and Hair Loss Treatment
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Cochlear Hair Cell Loss
03/16/13 @ 07:00:53 pm, Categories: Announcements [A], 276 words   English (US)

Neurotox Res. 2013 Mar 15. [Epub ahead of print]

Salicylate Selectively Kills Cochlear Spiral Ganglion Neurons by Paradoxically Up-regulating Superoxide.

Deng L, Ding D, Su J, Manohar S, Salvi R.

Source

Center for Hearing and Deafness, University at Buffalo, 137 Cary Hall, Buffalo, NY, 14214, USA.

Abstract

Aspirin and its active ingredient salicylate are potent antioxidants that have been reported to be neuro- and otoprotective. However, when consumed in large quantities, these drugs can cause temporary hearing loss and tinnitus. Moreover, recent studies indicate that after several days of treatment, salicylate selectively destroys the spiral ganglion neurons and auditory nerve fibers that relay sounds from the sensory hair cells to the brain. Why salicylate selectively damages spiral ganglion neurons while sparing the hair cells and supports cells is unclear. Here we show that high dose of salicylate trigger an apoptotic response in spiral ganglion neurons characterized morphologically by soma shrinkage and nuclear condensation and fragmentation plus activation of extrinsic initiator caspase-8 and intrinsic initiator caspase-9 several days after the onset of drug treatment. Salicylate treatment triggered an upsurge in the toxic superoxide radical only in spiral ganglion neurons, but not in neighboring hair cells and support cells. Mn TMPyP pentachloride, a cell permeable scavenger of superoxide blocked the expression of superoxide staining in spiral ganglion neurons and almost completely blocked the damage to the nerve fibers and spiral ganglion neurons. NMDA receptor activation is known to increase neuronal superoxide levels. Since NMDA receptors are mainly found on spiral ganglion neurons and since salicylate enhances NMDA receptor currents, the selective killing of spiral ganglion neurons is likely a consequence of enhanced and sustained activation of NMDA receptors by salicylate.

Organic Semiconductor

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blog
03/09/13 @ 10:35:07 pm, Categories: Announcements [A], 9 words   English (US)

hair loss blog

Organic semiconductor at the Smithsonian institution.

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Keratosis Pilaris
03/08/13 @ 11:17:59 pm, Categories: Announcements [A], 173 words   English (US)

J Dermatolog Treat. 2012 Apr 12. [Epub ahead of print]

Combination peel with incorporated fractional prickle coral calcium for the treatment of keratosis pilaris: a pilot study.

Park KY, et al

Abstract

Abstract Background: Keratosis pilaris (KP) is a common condition of follicular plugging with variable erythema. There is a lack of reliable response to the treatment of KP. Objective:We evaluated the effect and safety of combination peel with fractional prickle coral calcium (FCR™) in the treatment of KP. Materials and methods: Sixteen Korean patients were treated with FCR™ on both upper arms for five sessions at 2-week intervals. Clinical evaluations, mexameter measurements, and assessment of patients’ satisfaction and adverse events were performed at baseline and every visit. Results:After treatments, statistically significant improvements in the baseline KP were observed in erythema and melanin index of mexameter on treated upper arms. Both the physicians’ and patients’ assessments correlate with the results of mexameter scores. Conclusion: Our results suggest FCR™ should be considered as an effective and safe treatment option for the patients with KP.

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Hair Loss Treatment
03/04/13 @ 09:49:50 pm, Categories: Announcements [A], 95 words   English (US)

J Drugs Dermatol. 2013 Feb 1;12(2):e30-5.

Role of 5¨»-reductase inhibitors in androgen-stimulated skin disorders.

Azzouni F, et al

Abstract

5¦Á-reductase isozymes are ubiquitously expressed in human tissues. This enzyme family is composed of 3 members that perform several important biologic functions. 5¦Á-R isozymes play an important role in benign prostate hyperplasia, prostate cancer, and androgen-stimulated skin disorders, which include androgenic alopecia or male pattern Hair Loss and acne. This article reviews the pathophysiology of androgen-stimulated skin disorders and the key clinical trials using 5¦Á-R inhibitors in the treatment of androgen-stimulated skin disorders. J Drugs Dermatol. 2013;12(2):e30-e35.

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Hair
10/15/12 @ 09:55:46 am, Categories: Announcements [A], 26 words   English (US)

Hair loss blog at drproctor.com

Hair loss blog mn.st hair loss treatment blog

Hair loss blog skindrugs.com blog

Hair loss treatment peterproctor.com

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DC Psychiatrist Blog
10/15/12 @ 09:48:55 am, Categories: Announcements [A], 3 words   English (US)

DC Psychiatrist blog.

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Hair loss blogs
12/31/11 @ 11:27:20 am, Categories: Announcements [A], 26 words   English (US)

Hair loss blog at drproctor.com

Hair loss blog mn.st hair loss treatment blog

Hair loss blog skindrugs.com blog

Hair loss blog peterproctor.com

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Treatment for Pattern Hair Loss
12/21/11 @ 10:08:40 am, Categories: Announcements [A], 176 words   English (US)

J Dtsch Dermatol Ges. 2011 Oct;9 Suppl 6:S1-57. doi: 10.1111/j.1610-0379.2011.07802.x.

Guideline for the treatment of androgenetic alopecia in women and in men.

Blumeyer A, Tosti A, Messenger A, Reygagne P, Del Marmol V, Spuls PI, Trakatelli M, Finner A, Kiesewetter F, Trüeb R, Rzany B, Blume-Peytavi U; European Dermatology Forum (EDF).

Source

Department of Dermatology and Allergy, Clinical Research Center for Hair and Skin Science, Charité- Universitätsmedizin, Berlin, Germany.

Abstract

Androgenetic alopecia is the most common cause of hair loss… Patients diagnosed with androgenetic alopecia may undergo significant impairment of quality of life. Despite the high prevalence and the variety of therapeutic options available, there have been no national or international evidence-based guidelines for treatment. Therefore, the European Dermatology Forum (EDF) initiated a project to develop an evidence-based S3 guideline for the treatment of hair loss due to andro-genetic alopecia…..The purpose of the guideline is to provide dermatologists as well as general practitioners with an evidence-based tool for choosing an efficacious and safe therapy for patients with androgenetic alopecia.

edited for blog use.

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Smoking and hair loss in cancer patients
12/12/11 @ 03:52:17 pm, Categories: Announcements [A], 254 words   English (US)

Oncologist. 2011 Dec 1.

The Effect of Cigarette Smoking on Cancer Treatment-Related Side Effects.

Peppone LJ,
Abstract

AbstractBackground. Cigarette smoking has long been implicated in cancer development and survival. However, few studies have investigated the impact of smoking on symptom burden in cancer survivors during treatment and at survivorship stage. This study examines the influence of cigarette smoking on side effects among 947 cancer patients during and 6 months following treatment.Methods. Patients diagnosed with cancer and scheduled to receive chemotherapy and/or radiation therapy reported on current smoking status (yes, no) and total symptom burden [the sum of 12 common symptoms (fatigue, hair loss, memory, nausea, depression, sleep, pain, concentration, hot flashes, weight loss, skin problems, and dyspnea) scored on an 11-point scale ranging from 0 = “not present” to 10 = “as bad as you can imagine"] during treatment and at 6-month follow-up. The adjusted mean total symptom burden by smoking status was determined by analysis of covariance controlling for age, gender, race, education, occupation, treatment, cancer site, and Karnofsky performance score.Results. During treatment, smokers (S) had a significantly higher total symptom burden than nonsmokers (NS). At 6-month follow-up, smokers continued to report a higher total symptom burden than nonsmokers. Participants who quit smoking before treatment levels had a total symptom burden similar to nonsmokers.Conclusion. Smoking was associated with an increased symptom burden during and following treatments for cancer. Targeted cessation efforts for smokers to decrease symptom burden may limit the likelihood of treatment interruptions and increase quality of life following treatment.

Hair Loss Treatment at the Proctor clinic.

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Minoxidil not genotoxic in hair loss treatment
12/30/09 @ 09:37:52 am, Categories: Announcements [A], 185 words   English (US)

Toxicol Appl Pharmacol 1988;92:150

Nongenotoxicity of minoxidil in murine hair follicles….
Schop RN, Goldberg MT.

A 1-cm2 area on the back of CD1 mice was prepared for topical application of minoxidil,… by clipping or plucking hair from a patch of skin. Plucking stimulates hair follicle cell division while clipping does not. Minoxidil was topically administered for 8 consecutive days. CY or MNU was administered topically once on the eighth day postplucking. The incidence of nuclear aberrations and mitotic figures were measured in hair follicles while frequency of micronuclei and the ratio of RBC/PCE were measured in the bone marrow. Results with minoxidil showed no increase in either nuclear aberrations in the hair follicle or micronuclei in the bone marrow. These results suggest that topically applied minoxidil (as used for hair loss treatment) is not genotoxic. …. Minoxidil applied to clipped mice significantly increased the incidence of mitotic figures above that seen in both the clipped and plucked controls. This suggests that minoxidil is a mitogenic agent in the hair follicle. These findings are consistent with the success of topically applied minoxidil in the treatment of alopecia areata.

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Diabetese and alopecia-areata induced hair loss
11/27/09 @ 01:07:54 pm, Categories: Announcements [A], 334 words   English (US)

Sehgal VN, Bhattacharya SN, Sharma S, Srivastava G, Aggarwal AK. Alopecia areata progressing to totalis/universalis in non-insulin dependent diabetes mellitus (type II): Failure of dexamethasone-cyclophosphamide pulse therapy. Indian J Dermatol Venereol Leprol 2008;74:171-3

Sir,

The development of alopecia areata progressing to totalis/universalis in well-established non-insulin-dependent diabetes mellitus is an exclusive phenomenon, an indirect circumstantial evidence favoring it as an autoimmune disease. Dexamethasone-cyclophosphamide pulse was initiated but failed to produce a response.

A 47-year-old man, apparently well until a year ago….. His fasting and postprandial blood sugar levels were markedly elevated pointing to a diagnosis of NIDDM, for which oral anti-diabetics, along with dietary advice and appropriate oral and topical antibiotics were started. The preceding treatment ensured complete healing of the boils within 2 weeks. Four months later, he experienced spontaneous loss of hair over the legs progressing to involve other sites. In a short period of time, hair loss was noticed over the trunk, scalp and the beard area. It was accompanied by mild to moderate itching. However, hair loss was not preceded by any perifollicular papular or pustular lesions. The loss of hair over the scalp was total and was a source of embarrassment, which brought him for consultation. Examination of the skin was marked by loss of hair over the whole of the skin surface of the trunk, upper and lower extremities with patches of hair loss over the beard area. Hair pull test was positive. The complete loss of hair over the scalp was without any evidence of scarring or any skin lesion [Figure - 1], which was characteristic of AA. Routine total and differential leukocyte count, complete hemogram and blood biochemical parameters were within normal limits. However, his random blood sugar was 197 mg (normal up to 140) and glycosylated hemoglobin (HbA1c) was 9.6 percent (normal 9%-10% fair glycemic control). The hematoxylin eosin stained biopsy section from the area of hair loss showed dense lymphocytic infiltrate in the dermis involving the receding remnant of hair follicles….

Dr Proctor comments: unfortunately, dexamethasone treatment did not help.

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Early paper on hair loss due to X-rays
11/23/09 @ 04:04:40 pm, Categories: Announcements [A], 131 words   English (US)

J Exp Med. 1925;42:517

THE PRODUCTION OF PERSISTENT ALOPECIA IN RABBITS BY X-RAYS OF VARIOUS DEGREES OF HARDNESS.
Clark H, Sturm E.

1. The minimum dose of x-ray, of each of three degrees of hardness, required to produce persistent alopecia (hair loss) of the abdominal skin of normal white rabbits has been studied. 40 kilovolt rays filtered by 0.5 mm., 50 kilovolt rays filtered by 1 mm., and 70 kilovolt rays filtered by 1.5 mm. of aluminium were employed….snip…3. The values of the critical minimum doses expressed in terms of air ionization (pair of ions per gm. of air divided by 10(15)), for rays produced at 30, 40, 50, and 70 kilovolt peak, are 2.04, 3.7, 4.5, and over 5.1 respectively. The 30 kilovolt value is taken from a previous paper. 4. It is shown that the hair loss reaction deos not parallel to the erythema and pigmentation reactions.

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Hair loss treatment
11/21/09 @ 07:46:26 pm, Categories: Announcements [A], 5 words   English (US)

Dr Proctor treats hair loss

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Hair loss following radiation treatment
11/09/09 @ 04:03:10 pm, Categories: Announcements [A], 28 words   English (US)

AMA Arch Derm Syphilol1950;62:702

Case of possible prevention of permanent alopecia (hair loss) following roentgen therapy.
ROBINSON HM Sr.

An early paper on hair loss following radiation treatment

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Hair loss and hair regrowth in psoriasis
11/08/09 @ 09:17:01 am, Categories: Announcements [A], 120 words   English (US)

Dermatology. 1992;185:82

Psoriatic alopecia: acute and chronic hair loss in 47 patients with scalp psoriasis.
Runne U, Kroneisen-Wiersma P.

Edited for blog use

Symptomatic hair loss and alopecia were seen in psoriatic lesions of the scalp in 47 patients. Remarkably, in 66% of the cases it was an inaugural manifestation, and in 36% the scalp was exclusively involved. ..snip… Hair loss varied in intensity from protracted to moderate and massive. It presented as acute, chronic or chronic recurrent. Thirteen patients became aware of the hair loss with the beginning of therapy. The alopecia was found to be circumscribed in 75% of the cases and diffuse in 25%. snip.. After topical antipsoriatic treatment, most of the reexamined patients showed complete hair regrowth, while 5 developed a residual scarring. snip…

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Oral contraceptives and hair loss
11/03/09 @ 10:08:15 pm, Categories: Announcements [A], 105 words   English (US)

Dermatol Iber Lat Am. 1970;12:29-36.

Oral contraceptives and hair loss

Greenwald AE.

PIP: 5 cases of diffuse hair loss in women who took oral contraceptives are studied. 3 cases developed male pattern baldness during the time they were taking the pills. 2 cases began losing their hair after having stopped medication and these resembled postpartum baldness. 1 woman did not regrow her hair 20 months after having stopped medication . The effects of female sex hormones on hair follicles are discussed. Contraceptives induce a condition of pseudopregnancy, and should be considered as possible toxic causes of hair loss. However, the incidence of hair loss among users of oral contraceptives is very low.

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Hair follicle transglutamases
10/31/09 @ 05:41:16 am, Categories: Announcements [A], 152 words   English (US)

Mol Cell Biochem. 1984;58:99

Epidermal and hair follicle transglutaminases and crosslinking in skin.

Peterson LL, Wuepper KD.

Epidermal and hair follicle transglutaminases crosslink structural proteins in the skin by epsilon-(gamma-glutamyl)-lysine bonds. This crosslinking produces protein polymers that are extremely insoluble and, until recently, difficult to characterize. Epidermal transglutaminase is localized to the granular layer of the epidermis. It catalyzes the crosslinking of a soluble cytoplasmic precursor to form the cornified envelope that lines the inner membrane of the mature keratinocyte in the stratum corneum. Hair follicle transglutaminase is localized to the inner root sheath and medulla of the hair follicle. It crosslinks a poorly characterized citrulline-rich protein. The enzymes and their substrates have been shown to be important markers of normal differentiation. Regulation of these processes is currently under investigation.

Added: This enzyme may have a role in hair regrowth,hair loss and hair loss treatment.

edited for hair loss blog

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Hairs are also lost in the ear
10/31/09 @ 05:35:21 am, Categories: Announcements [A], 258 words   English (US)

Laryngoscope. 2009.29.

Spiral ganglion loss outpaces inner hair cell loss in endolymphatic hydrops.

Momin SR, et al

OBJECTIVES/HYPOTHESIS:: Neuronal toxicity is thought to be important in Meniere’s disease and experimental endolymphatic hydrops (ELH). This study quantifies the relationship between neuronal degeneration and hair cell degeneration in ELH to evaluate the hypothesis that a primary neural insult would yield greater loss in the spiral ganglion than at the inner hair cell level. STUDY DESIGN:: Following induction and histopathologic confirmation of endolymphatic hydrops in guinea pigs, the degree of hydrops, spiral ganglion loss, and hair cell degeneration were quantified and compared. METHODS:: Guinea pigs with surgically induced unilateral hydrops were sacrificed and their cochleas preserved. Hydrops severity and spiral ganglion density were quantified using automated methods. Hair cells were counted manually. Values were normalized against the contralateral ear to create loss indexes. RESULTS:: Inner hair cell (IHC) loss at the apex is significantly lower than corresponding neuronal loss. IHC loss at the base is also lower than neuron loss, although not significantly. Regression analysis shows a significant, positive correlation between neuron loss severity and IHC loss severity at the apex, but not at the base. There is no correlation between hydrops severity and inner hair cell loss. CONCLUSIONS:: By confirming that spiral ganglion loss is more severe than hair cell loss, and that hair cell loss appears to worsen with neuronal degeneration, this study supports the theory that neuronal toxicity is the primary insult in ELH-related disorders, such as Meniere’s disease, and may provide the basis for designing treatment strategies.

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Loss of hair cells in the inner ear
10/29/09 @ 05:04:11 pm, Categories: Announcements [A], 188 words   English (US)

J Vis Exp. 2009;2: 1211.doi:10.3791

Gross and fine dissection of inner ear sensory epithelia in adult zebrafish.
Liang J, Burgess SM.

changed for hair loss blog use

Neurosensory epithelia in the inner ear are the crucial structures for hearing and balance functions. Therefore, it is important to understand the cellular and molecular features of the epithelia, which are mainly composed of two types of cells: hair cells (HCs) and supporting cells (SCs). Here we choose to study the inner ear sensory epithelia in adult zebrafish not only because the epithelial structures are highly conserved in all vertebrates studied, but also because the adult zebrafish is able to regenerate hair cells, an ability that mammals lose shortly after birth. We use the inner ear of adult zebrafish as a model system to study the mechanisms of inner ear hair cell regeneration in adult vertebrates that could be helpful for treatment of hearing/balance deficits in human as a result of hair cell loss. Here we demonstrate how to do gross and fine dissections of inner ear sensory epithelia in adult zebrafish. ..snip..

Loss of hair cells in the inner ear

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treatment of polycyctic ovarian disease
10/24/09 @ 08:25:32 pm, Categories: Announcements [A], 87 words   English (US)

Endocrinol Metab Clin North Am.1988;17(4):785

edited

Evaluation and therapy of polycystic ovarian syndrome.Loy R, Seibel MM.

The amenorrhea associated with bilateral polycystic ovaries represents a syndrome involving various organs and systems. Clinically, this presents as menstrual disturbances, infertility, excessive body weight, excess hair growth and scalp hair loss. ..snip… To date, the available GnRH agonists have not been found selective enough to be used in the treatment of excess hair growth, owing to possible long-term complications. Most medical approaches should include electrolysis for permanent hair loss.

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Drug-related hair loss
10/23/09 @ 09:26:36 pm, Categories: Announcements [A], 78 words   English (US)

Dermatol Clin. 1987 Jul;5(3):571

Drug-related hair loss.

Brodin MB.

Drugs and chemicals are capable of producing a wide spectrum of hair loss, ranging from barely detectable hair shedding to frank, irreversible baldness. Agents may act directly or indirectly upon the follicle, but in either case, diagnosis of subtle hair loss can be difficult. General aspects of the clinical and research problems have been discussed, and 40 drugs and drug classes that have been linked to hair disturbances have been reviewed.

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Human hair growth in vitro.
10/09/09 @ 07:39:22 pm, Categories: Announcements [A], 212 words   English (US)

J Cell Sci. 1990 Nov;97 ( Pt 3):463-71.

Human hair growth in vitro.

Philpott MP, et al

We report for the first time the successful maintenance and growth of human hair follicles in vitro. Human anagen hair follicles were isolated by microdissection from human scalp skin. Isolation of the hair follicles was achieved by cutting the follicle at the dermo-subcutaneous fat interface using a scalpel blade. Intact hair follicles were then removed from the fat using watchmakers’ forceps. Isolated hair follicles maintained free-floating in supplemented Williams E medium in individual wells of 24-well multiwell plates showed a significant increase in length over 4 days. The increase in length was seen to be attributed to the production of a keratinised hair shaft, and was not associated with the loss of hair follicle morphology. [methyl-3H]thymidine autoradiography confirmed that in vitro the in vivo pattern of DNA synthesis was maintained; furthermore, [35S]methionine labelling of keratins showed that their patterns of synthesis did not change with maintenance. The importance of this model to hair follicle biology is further demonstrated by the observations that TGF-beta 1 has a negative growth-regulatory effect on hair follicles in vitro and that EGF mimics the in vivo depilatory effects that have been reported in sheep and mice.

Hair loss and hair loss treatment

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Human hair growth in vitro.
10/09/09 @ 07:35:42 pm, Categories: Announcements [A], 212 words   English (US)

J Cell Sci. 1990 Nov;97 ( Pt 3):463-71.

Human hair growth in vitro.

Philpott MP, et al

We report for the first time the successful maintenance and growth of human hair follicles in vitro. Human anagen hair follicles were isolated by microdissection from human scalp skin. Isolation of the hair follicles was achieved by cutting the follicle at the dermo-subcutaneous fat interface using a scalpel blade. Intact hair follicles were then removed from the fat using watchmakers’ forceps. Isolated hair follicles maintained free-floating in supplemented Williams E medium in individual wells of 24-well multiwell plates showed a significant increase in length over 4 days. The increase in length was seen to be attributed to the production of a keratinised hair shaft, and was not associated with the loss of hair follicle morphology. [methyl-3H]thymidine autoradiography confirmed that in vitro the in vivo pattern of DNA synthesis was maintained; furthermore, [35S]methionine labelling of keratins showed that their patterns of synthesis did not change with maintenance. The importance of this model to hair follicle biology is further demonstrated by the observations that TGF-beta 1 has a negative growth-regulatory effect on hair follicles in vitro and that EGF mimics the in vivo depilatory effects that have been reported in sheep and mice.

Hair loss and hair loss treatment

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Topical minoxidil in hair loss
10/06/09 @ 02:25:46 pm, Categories: Announcements [A], 120 words   English (US)

Drugs. 1987 Feb;33(2):107-22.

Topical minoxidil..
Clissold SP, Heel RC.

Oral minoxidil causes body hair growth. Consequently, topical minoxidil is used to improve hair regrowth in patients with alopecia areata and male pattern hair loss. Topical minoxidil promotes cosmetically acceptable hair regrowth in some cases of alopecia areata. Acceptible results are achieved in about one-third of subjects with male pattern hair loss. snip… Less severe pattern hair loss predicts response. Thus, topical minoxidil is a reasonable for patients with alopecia androgenetica. snip.. Results from treating patients with alopecia areata with topical minoxidil, although encouraging, have been more variable and require further evaluation. Topical minoxidil is apparently the first available drug with the potential to promote substantial hair regrowth in these divergent diseases.

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Management of androgenetic alopecia
10/01/09 @ 11:03:05 pm, Categories: Announcements [A], 273 words   English (US)

J Eur Acad Dermatol Venereol. 1999 May;12(3):205-14.

Management of androgenetic alopecia (male pattern hair loss).

Tosti A, Camacho-Martinez F, Dawber R.

BACKGROUND: Androgenetic alopecia (AGA) is the most frequent cause of hair loss affecting up to 50% of men and 40% of women by the age of 50. METHODS: This paper outlines the current status of diagnosis and offers guidelines for optimal management of AGA in both men and women. RESULTS: The diagnosis of AGA can usually be confirmed by medical history and physical examination alone. A trichogram can be useful to assess the progression of the hair loss. A scalp biospy is diagnostic but usually not required. In women with signs of hyperandrogenism, investigation for ovarian (polycystic ovarian disease) or adrenal (late-onset congenital adrenal hyperplasia) disorders is required. Mild to moderate AGA in men can be treated with oral finasteride or topical minoxidil. Oral finasteride at the dosage of 1 mg/day produced clinical improvement in up to 66% of patients treated for 2 years. The drug is effective for both frontal and vertex hair thinning. Medical treatment with finasteride or minoxidil should be continued indefinitely since interruption of therapy leads to hair loss with return to pretreatment status. Mild to moderate AGA in women can be treated with oral antiandrogens (cyproterone acetate, spironolactone) and/or topical minoxidil with good results in many cases. Hair systems and surgery may be considered for selected cases of severe AGA both in men and in women. CONCLUSIONS: Patients with AGA should be informed about the pathogenesis of the condition. If used correctly, available medical treatments arrest progression of the disease and reverse miniaturization in most patients with mild to moderate AGA.

PMID: 10461639

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09/24/09 @ 11:38:15 am, Categories: Announcements [A], 189 words   English (US)

Clin Dermatol. 1988 Oct-Dec;6(4):129-31.

Retinoids: compounds important to hair growth
.
Terezakis NK, Bazzano GS.

Dermatology Research Foundation, Los Angeles, California.

hair loss blog

Although the mechanisms of follicular regression in androgenetic alopecia are not fully understood, retinoids may be important in changing the status of regressing follicles. There are many reports documenting reversal of epithelial dysplastic changes with retinoids. Although none of the studies with retinoids have concentrated on the precise mechanisms of follicular growth (regression or regeneration), these limited observations, and our early studies suggest that further work should be done on the effect retinoids have on the hair follicle during the various growth and regression phases of the follicular life cycle in humans. We propose that certain retinoids increase the rate of hair growth, prolong the anagen phase of the hair cycle, play a role in converting vellus to terminal hairs, and act synergistically with minoxidil to produce more dense hair regrowth from regressing follicles than either compound alone. Larger controlled studies and better methods for assessing hair growth are necessary to support these early results. Other retinoids as well as certain minoxidil analogs should also be studied.

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Hair Loss Treatment Blogs
09/23/09 @ 01:04:29 pm, Categories: Announcements [A], 297 words   English (US)

Hair loss and Hair Loss Treatment blogs

1. Hair Loss Blog

2. Hair Loss Blog

3. Hair Loss Blog

4. Hair Loss treatment Blog

J Dermatol Sci. 2004 Apr;34(2):91-8.

Effect of minoxidil on proliferation and apoptosis in dermal papilla cells of human hair follicle.

Han JH, Kwon OS, Chung JH, Cho KH, Eun HC, Kim KH.

BACKGROUND: Minoxidil has been widely used to treat androgenetic alopecia, but little is known about its pharmacological activity or about the identity of its target cells in hair follicles. We hypothesized that minoxidil has direct effects on the proliferation and apoptosis of dermal papilla cells (DPCs) of human hair follicle. OBJECTIVE: To elucidate the mechanism of topical minoxidil action in terms of stimulating hair growth. METHODS: We evaluated cell proliferations in cultured DPCs by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) and measured the expressions of extracellular signal-regulated kinase (ERK), Akt, Bcl-2, and Bax by Western blot. We also measured elongation of hair follicles in organ culture. RESULTS: Minoxidil significantly increased the proliferation of DPCs. The levels of ERK phosphorylation and of phosphorylated Akt increased significantly 1 h post-treatment; percentage increase of ERK phosphorylation was 287% at 0.1 microM and 351% at 1.0 microM of minoxidil, and that of Akt phosphorylation was 168% at 0.1 microM and 257% at 1.0 microM of minoxidil. 1.0 microM of minoxidil increased Bcl-2 expression over 150%, while 1.0 microM of minoxidil decreased Bax expression by more than 50%. Moreover, a significant elongation of individual hair follicles in organ culture was observed after adding minoxidil. CONCLUSION: Minoxidil promotes the survival of human DPCs by activating both ERK and Akt and by preventing cell death by increasing the ratio of Bcl-2/Bax. We suggest that minoxidil stimulates the growth of human hairs by prolonging anagen through these proliferative and anti-apoptotic effects on DPCs.

Hair loss blogs

5. Hair Loss Blog

6. Hair Loss Blog

7. Hair Loss treatment Blog

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Status of scalp hair and therapy of alopecia in men in Switzerland
09/17/09 @ 09:19:06 am, Categories: Announcements [A], 252 words   English (US)

Praxis (Bern 1994). 2001 Feb 15;90(7):241-8.

Status of scalp hair and therapy of alopecia in men in Switzerland

Trüeb RM, de Viragh PA;

A community-based interview and a questionnaire of men visiting the dermatologist for treatment of hair loss were conducted in Switzerland, to characterize the significance of scalp hair and self-perception of hair loss in Swiss men, and to evaluate current treatment of hair loss. 508 men, aged 15-74 years, regardless of the degree of hair loss, were interviewed by telephone, and 308 patient questionnaires were completed by 19 dermatologists. The questions addressed by the interview were: degree of self-rated hair loss, time invested for hair care, use or reasons for rejecting hair growing agents, relevant criteria for scalp hair, self-assessment with respect to different “hair communication types". The questionnaire analysed the causes of hair loss, prior and current treatment modalities, and follow-up at the dermatologist. Respondents rated their hair loss on a 5-point, textual scale that ranged from ‘no hair loss’ to ‘bald areas’. 43% reported hair loss to some extent. For 42% a full head of hair was very important, especially for men under 29 years, who invested more time for hair care and had not lost hair. Of men with hair loss, 26% previously applied hair growing agents. Of men consulting the dermatologist for hair loss, 90% had androgenetic alopecia. 37% were previously treated: prior treatment was in 59% minoxidil, in 4% finasteride (Propecia), in 7% Aminexil, in 7% dietary supplements, and in 6% conducted by the hair dresser. In 79% treatment was switched to Propecia: of these, 73% adhered to the follow-up consultations at the dermatologist.

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Severe hypertrichosis of the external ear canal during minoxidil therapy
09/13/09 @ 01:26:22 am, Categories: Announcements [A], 109 words   English (US)

Arch Otolaryngol Head Neck Surg. 1988 Aug;114(8):918-9.

Severe hypertrichosis of the external ear canal during minoxidil therapy.
Toriumi DM, Konior RJ, Berktold RE.

Minoxidil is a potent peripheral vasodilator used to treat patients with severe hypertension that is unresponsive to other medications. Hypertrichosis of the forehead, face, neck, shoulders, upper part of the arms, and legs is a frequent side effect that occurs in the majority of patients that use this drug. This phenomenon appears to be due to increased blood flow to hair follicles, with resultant excessive hair growth. We describe a patient with severe hypertrichosis of the external ear canal resulting in chronic otitis externa and hearing loss.

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Genetic analysis of male pattern baldness and the 5alpha-reductase genes
09/11/09 @ 10:48:09 am, Categories: Announcements [A], 236 words   English (US)

J Invest Dermatol. 1998 Jun;110(6):849-53.

Genetic analysis of male pattern baldness and the 5alpha-reductase genes.

Ellis JA, Stebbing M, Harrap SB.

Genetic predisposition and androgen dependence are important characteristics of the common patterned loss of scalp hair known as male pattern baldness. The involvement of the 5alpha-reductase enzyme in male pattern baldness has been postulated due to its role in the metabolism of testosterone to dihydrotestosterone. There are two known isozymes of 5alpha-reductase. Type I has been predominantly localized to the skin and scalp. Type II, also present on the scalp, is the target of finasteride, a promising treatment for male pattern baldness. We conducted genetic association studies of the 5alpha-reductase enzyme genes (SRD5A1 on chromosome 5 and SRD5A2 on chromosome 2) using dimorphic intragenic restriction fragment length polymorphisms. From a population survey of 828 healthy families comprising 3000 individuals, we identified 58 young bald men (aged 18-30 y) and 114 older nonbald men (aged 50-70 y) for a case control comparison. No significant differences were found between cases and controls in allele, genotype, or haplotype frequencies for restriction fragment length polymorphisms of either gene. These findings suggest that the genes encoding the two 5alpha-reductase isoenzymes are not associated with male pattern baldness. Finally, no clear inheritance pattern of male pattern baldness was observed. The relatively strong concordance for baldness between fathers and sons in this study was not consistent with a simple Mendelian autosomal dominant inheritance. A polygenic etiology should be considered.

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hair-grafting in between existing follicles in patients with early pattern baldness
09/08/09 @ 11:55:03 am, Categories: Announcements [A], 229 words   English (US)

Dermatol Surg. 2000 Aug;26(8):801-5.

A technique for hair-grafting in between existing follicles in patients with early pattern baldness.
Brandy DA.

BACKGROUND: When using follicular hair transplantation on patients with early male or female pattern baldness, there can be significant trauma to preexisting hair follicles. This becomes especially important in view of the fact that finastride and minoxidil can stop or slow hair loss. OBJECTIVE: To develop a system that averts damage to preexisting hair follicles in patients with early male or female pattern baldness. METHODS: A Lutex headlight (2.5-3.5x loupe magnification system) is used to make 1.0-1.5 mm spear incisions in between the hair follicles in patients with early male or female pattern balding. Magnification is also utilized during the graft cutting and placement phases of the operation. RESULTS: This headlight-loupe magnification system has dramatically decreased the amount of permanent hair loss and anagen effluvium on 144 patients with early male and female pattern baldness. With less permanent hair loss there is greater density observed with each progressive session. CONCLUSION: Hair surgeons now have a method to consistently and significantly minimize the amount of damage to preexisting hair follicles in patients in the early stages of male and female pattern baldness. This becomes even more important in light of the fact that more and more patients are using finastride or minoxidil to stop the thinning process. Existing hairs can therefore be preserved.

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Hair loss pattern due to chemotherapy-induced anagen effluvium
09/05/09 @ 04:16:33 pm, Categories: Announcements [A], 195 words   English (US)

Hair loss pattern due to chemotherapy-induced anagen effluvium
Dermatology. 2007;215(1):36-40.

Hair loss pattern due to chemotherapy-induced anagen effluvium: a cross-sectional observation.

Yun SJ, Kim SJ.

BACKGROUND: Anagen effluvium is a common side effect of chemotherapy, but few studies have examined its clinical characteristics. OBJECTIVE: This study was aimed at evaluating the hair loss caused by chemotherapeutic agents. METHODS: Sixty-four patients with anagen effluvium were evaluated in the study. Chemotherapeutic agents were classified into 5 different groups. The pattern of hair loss was analyzed when specific involvement of the hairline was obvious. RESULTS: Forty-six (71.9%) of the 64 total patients maintained hairs along their hairline. Hairs were maintained with a total hairline in 20 (31.3%), frontal hairline in 13 (20.3%) and occipital hairline in 12 (18.8%) patients. Among the 20 males with patterned hair loss, the following hairlines were preserved: occipital in 10 (50%), total in 7 (35%) and frontal in 3 (15%). Among the 25 females with patterned hair loss, hairlines were preserved as total in 13 (52%), frontal in 10 (40%) and occipital in 2 (8%). However, no significant differences were detected in hair loss patterns according to age, associated symptoms, chemotherapeutic agent group or combination of chemotherapeutic agents. CONCLUSION: Our results suggest that anagen effluvium induced by chemotherapeutic agents represents patterned hair loss. 2007 S. Karger AG, Basel

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Selenium
09/05/09 @ 04:15:01 pm, Categories: Announcements [A], 198 words   English (US)

Selenium toxicity
Sci Total Environ. 2009 Jun 1;407(12):3620-33.

The essential toxin: the changing perception of selenium in environmental sciences.
Lenz M, Lens PN.

During the last decades, the perception of selenium has undergone substantial changes. While its toxic effects were recognized causing hair and hoof loss in animals during the 1930s, its essential role in microbial, animal and human metabolism has been recognized later, i.e. with the discovery of selenium deficiency causing “white muscle disease” in feedstock in the 1950s. Nowadays, the positive effect of systematic selenium supplementation is discussed in manifold topics such as cancer or diabetes prevention and avian influenza susceptibility. Treatment of selenium containing waste streams poses a notable challenge to environmental engineers, and to date no ultimate solution has been found for e.g. the selenium contamination in agricultural areas of the western USA. For the future, selenium contamination carries an imminent danger, if the increasing energy demand is covered by fossil fuel combustion, which will lead to major selenium emission and toxicity. This review presents current knowledge of selenium’s role in environmental sciences and outlines potentially feasible treatment options targeting a variety of selenium contaminated waste streams.

Hair Loss and hair loss treatment

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Traction alopecia
09/05/09 @ 04:08:50 pm, Categories: Announcements [A], 251 words   English (US)

Br J Dermatol. 2009 Jan;160(1):62-8. Epub 2008 Sep 22.

Cicatricial marginal alopecia: is it all traction?

Goldberg LJ.

BACKGROUND: In a specialized hair loss clinic, a group of patients was identified with focal or complete hair loss at the scalp periphery, with a normal scalp surface. Biopsy revealed complete loss of individual hair follicles, indicative of scarring alopecia. Not all patients had a history supportive of a diagnosis of traction alopecia. OBJECTIVES: To identify and characterize further patients with scarring alopecia of the scalp margin using a retrospective review. METHODS: All biopsies of scarring alopecia carried out by a single clinician between 1 January 1999 and 29 September 2006 were reviewed. Patients in whom the hair loss was located at the periphery of the scalp were selected for retrospective chart review. RESULTS: A total of 15 patients met the study criteria, which included histological scarring alopecia and hair loss of the scalp margin. Six of the patients gave a history of relaxing or straightening their hair. Six denied hair care practices sufficient to cause traction alopecia. In three patients, the hair care history was unknown. Occipital hair loss was a common clinical finding, mimicking alopecia areata. The presence of scarring was often subtle histologically. CONCLUSIONS: A group of patients with moderate to severe cicatricial alopecia of the scalp margin is described. The presence of scarring is difficult to diagnose both clinically and histologically. The lack of a history of severe traction or harsh styling practices in half the patients casts doubt on whether or not traction is the only

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09/02/09 @ 02:44:22 pm, Categories: Announcements [A], 4 words   English (US)

Hair Loss Treatment Blog

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the murine hair follicle
08/29/09 @ 03:59:01 pm, Categories: Announcements [A], 261 words   English (US)

J Invest Dermatol. 2004 Nov;123(5):880-7.

Expression of CD200 on epithelial cells of the murine hair follicle: a role in tissue-specific immune tolerance?

Rosenblum MD, Olasz EB, Yancey KB, Woodliff JE, Lazarova Z, Gerber KA, Truitt RL.
Department of Pediatrics, Medical College of Wisonsin, Milwaukee, Wisconsin, USA.

CD200 (OX-2) is a transmembrane glycoprotein that transmits an immunoregulatory signal through the CD200 receptor (CD200R) to attenuate inflammatory reactions and promote immune tolerance. CD200 expression in the skin has not been described previously. We now report that freshly isolated cells of the murine epidermis contain a subpopulation of major histocompatibility complex (MHC) class II-negative, CD3-negative keratinocytes that are CD200-positive. CD200 expression was accentuated in keratinocytes comprising the outer root sheath of the murine hair follicle (HF). When syngeneic skin grafts were exchanged between gender-matched wild-type (WT) and CD200-deficient C57BL/6 mice, significant perifollicular and intrafollicular inflammation was observed, eventually leading to the destruction of virtually all HF (alopecia) without significant loss of the CD200-negative grafts. Minimal and transient inflammation was observed in WT grafts, which persisted long term with hair. There was a 2-fold increase in graft-infiltrating T cells in CD200-deficient skin at 14 d. Alopecia and skin lesions were induced in CD200-deficient hosts by adoptive transfer of splenocytes from WT mice previously grafted with CD200-negative skin, but not from mice grafted with WT skin. Collectively, these results suggest that the expression of CD200 in follicular epithelium attenuates inflammatory reactions and may play a role in maintaining immune tolerance to HF-associated autoantigens.

Hair loss and Hair loss treatment

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Finasteride in the treatment of Hair Loss
08/28/09 @ 10:45:13 pm, Categories: Announcements [A], 123 words   English (US)

Expert Opin Pharmacother. 2004 Apr;5(4):933-40.

Finasteride in the treatment of alopecia.

Libecco JF, Bergfeld WF.

Finasteride is a 5alpha-reductase inhibitor approved for the treatment of male pattern hair loss. Originally approved for the treatment of benign prostatic hypertrophy in 1992, its approval was expanded in 1997 to include the treatment of androgenetic alopecia (AGA) in men at a dose of 1 mg/day. Finasteride inhibits 5alpha-reductase, thereby prohibiting the conversion of testosterone to dihydrotestosterone (DHT), which is implicated in the development of hair loss in some men. Reduction in DHT results in a significant improvement in subjective and objective assessments of hair growth and density. Finasteride is well-tolerated with a favourable adverse event history. The most common adverse events include reduced libido, decreased ejaculate volume and gynaecomastia.

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